Armstrong DG, Swerdlow MA, Armstrong AA, Conte MS, Padula WV, Bus SA Five year mortality and direct costs of care for people with diabetic foot complications are comparable to cancer. J Foot Ankle Res. 2020; 24;13:(1)

Atkin L, Bucko Z, Conde Montero E Implementing TIMERS: the race against hard-to-heal wounds. J Wound Care. 2019; 23:S1-S50

Boulton AJM, Armstrong DG, Kirsner RS Diagnosis and management of diabetic foot complications.: American Diabetes Association; 2018

Feight J, Forsyth A, Tettelbach W Navigating obstacles impacting the sustainability of Medicare-funded wound care pricing. J Wound Care. 2023; 32:(11)720-726

Fiedler LR, Schönherr E, Waddington R Decorin regulates endothelial cell motility on collagen I through activation of insulin-like growth factor I receptor and modulation of alpha2beta1 integrin activity. J Biol Chem. 2008; 283:(25)17406-17415

JWC Masterclasses. Cellular, acellular and matrix-like products (CAMPS). 2023. https// (accessed 12 February 2024)

Koob TJ, Lim JJ, Massee M, Zabek N, Denozière G Properties of dehydrated human amnion/chorion composite grafts: Implications for wound repair and soft tissue regeneration. J Biomed Mater Res B Appl Biomater. 2014; 102:(6)1353-1362

Lavery LA, Armstrong DG, Wunderlich RP, Mohler MJ, Wendel CS, Lipsky BA Risk factors for foot infections in individuals with diabetes. Diabetes Care. 2006; 29:(6)1288-1293

National Institute for Health and Care Excellence. Diabetic foot problems: prevention and management. NICE guideline NG19. 2015. https// (accessed 7 February 2024)

Orgel JP, San Antonio JD, Antipova O Molecular and structural mapping of collagen fibril interactions. Connect Tissue Res. 2011; 52:(1)2-17

Skin substitutes. 2024. https// (accessed 7 February 2024)

Schultz GS, Barillo DJ, Mozingo DW, Chin GA Wound bed preparation and a brief history of TIME. Int Wound J. 2004; 1:(1)19-32

Schultz G, Bjarnsholt T, James GA Consensus guidelines for the identification and treatment of biofilms in chronic nonhealing wounds. Wound Repair Regen. 2017; 25:(5)744-757

Skin substitutes for treating chronic wounds. 2020. https// (accessed 7 February 2024)

Tettelbach WH, Armstrong DG, Chang TJ Cost-effectiveness of dehydrated human amnion/chorion membrane allografts in lower extremity diabetic ulcer treatment. J Wound Care. 2022; 31:S10-S31

Tettelbach W, Forsyth A Specialty specific quality measures needed to improve outcomes in wound care. Int Wound J. 2023; 20:(5)1662-1666

Tettelbach W, Driver V, Oropallo A Treatment patterns and outcomes of Medicare enrolees who developed venous leg ulcers. J Wound Care. 2023; 32:(11)704-718

Wu S, Carter M, Cole W Best practice for use of biomaterials: a new definition and categorisation – CAMPs. J Wound Care. 2023; 32:(4)S1-S32

Current practices using cellular, acelluar and matrix-like products (CAMPs)

22 February 2024
Volume 33 · Issue 4

Cellular, acellular and matrix-like products (CAMPs), formerly referred to as skin substitutes, are a therapeutic class of materials that when applied can provide a barrier over open hard-to heal wounds. In the proper setting, these products have the potential to create a more favourable wound bed environment that can encourage granulation tissue growth as well as epithelial cell migration across the extracellular matrix, thus re-establishing the trajectory towards closure. Wound closure minimises infection risk, fluid loss, and reduces pain.

The term skin substitutes can be misleading in that these products do not fully replace the integumentum when applied, but most do replicate some properties of normal skin and are thus an important adjunct in the treatment of acute or chronic wounds (Shahrokhi, 2024).

This article reviews changes in the understanding and use of CAMPs that health professionals, such as tissue viability and community nurses who provide direct wound care, should know.

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